Recombinant CDSE1 antibody

Catalog No. ABIN7880471

This Rabbit Monoclonal antibody specifically detects CDSE1 in WB and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant CDSE1 antibody (ABIN7880471)

Target: CDSE1 (Cold Shock Domain Containing E1, RNA-Binding (CDSE1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CDSE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: 30C76

Product Details anti-CDSE1 Antibody

Purpose: CSDE1 Antibody / Cold shock domain containing E1

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human CSDE1 was used as the immunogen for the CSDE1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CSDE1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the CSDE1 antibody at -20oC.

Target Details for CDSE1

Target: CDSE1 (Cold Shock Domain Containing E1, RNA-Binding (CDSE1))

Alternative Name: CSDE1

Background: CSDE1 antibody detects cold shock domain containing E1, an RNA-binding protein also known as UNR (upstream of N-ras). CSDE1 contains multiple cold shock domains that allow it to interact with RNA and regulate processes such as translation, RNA stability, and internal ribosome entry site (IRES)-mediated initiation. Its wide influence on gene expression positions CSDE1 as a key regulator of cellular adaptation and developmental programs.

Research using CSDE1 antibody has linked the protein to diverse biological processes. In embryogenesis, CSDE1 regulates translation of transcripts required for cell differentiation. In cancer, aberrant CSDE1 activity promotes tumor progression by stabilizing oncogenic mRNAs and enhancing their translation. Studies have shown that high CSDE1 expression is associated with melanoma, prostate cancer, and neuroblastoma, highlighting its role in malignancy. Conversely, CSDE1 also regulates apoptosis-related transcripts, underscoring its complex function in cell fate control.

CSDE1 has additional roles in viral biology, where it regulates the translation of viral RNAs that depend on IRES elements. Viruses such as poliovirus and hepatitis C exploit CSDE1 to enhance replication. Its dual function in host and viral RNA regulation makes it a subject of interest in infection research. In neurons, CSDE1 has been implicated in local translation within axons and dendrites, influencing synaptic plasticity and neuronal survival.

Antibodies against CSDE1 are validated for western blot, immunoprecipitation, immunofluorescence, and immunohistochemistry. These reagents allow detection of CSDE1 expression patterns, RNA-binding activities, and protein interactions. Clone-based antibodies provide high specificity for reproducible results across systems.

NSJ Bioreagents supplies this CSDE1 antibody for research into RNA regulation, cancer biology, and virology.

UniProt: O75534

Pathways: SARS-CoV-2 Protein Interactome