DOK7 antibody

Catalog No. ABIN7880641

The Rabbit Polyclonal anti-DOK7 antibody (ABIN7880641) specifically detects DOK7 in WB, FACS and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for DOK7 antibody (ABIN7880641)

Target: DOK7 (Docking Protein 7 (DOK7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOK7 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DOK7 Antibody

Purpose: DOK7 Antibody / Docking protein 7

Sequence: STVEERVAQE ALETLQLEKR LSLLSHAGR

Purification: Antigen affinity purified

Immunogen: Amino acids STVEERVAQEALETLQLEKRLSLLSHAGR from the human protein were used as the immunogen for the DOK7 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the DOK7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the DOK7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for DOK7

Target: DOK7 (Docking Protein 7 (DOK7))

Alternative Name: DOK7

Background: Dok-7 is a non-catalytic cytoplasmic adaptor protein that is expressed specifically in muscle and is essential for the formation of neuromuscular synapses. Further, Dok-7 contains pleckstrin homology (PH) and phosphotyrosine-binding (PTB) domains that are critical for Dok-7 function. It is mapped to 4p16.3. The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.

UniProt: Q18PE1

Pathways: Skeletal Muscle Fiber Development