DRAP1 antibody

Catalog No. ABIN7880658

The Mouse Monoclonal anti-DRAP1 antibody is suitable to detect DRAP1 in samples from Human. It has been validated for WB, IF and FACS.

Quick Overview for DRAP1 antibody (ABIN7880658)

Target: DRAP1 (DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DRAP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-DRAP1-1A12

Product Details anti-DRAP1 Antibody

Purpose: NC2 alpha Antibody / DRAP1

Purification: Protein A/G affinity

Immunogen: Recombinant human protein was used as the immunogen for the NC2 alpha antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the NC2 alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the NC2 alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for DRAP1

Target: DRAP1 (DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1))

Alternative Name: NC2 alpha

Background: NC2 (negative cofactor 2) is a dimeric histone-fold complex that represses RNA polymerase II transcription through binding to TBP and inhibiting the transcription factors TFIIA and TFIIB. NC2 consists of two subunits, termed NC2a and NC2beta, and these subunits dimerize and bind to TBP-promoter complexes via histone fold domains of the H2A-H2B type. NC2 associates with promoters in a manner that correlates with transcriptional activity and with occupancy by basal transcription factors. NC2 binds directly to DNA, and the binding of NC2 to TBP-promoter complexes affects the conformation of DNA, and results in the inhibition of TFIIB.

UniProt: Q14919