ERCC1 antibody

Catalog No. ABIN7880754

The Rabbit Monoclonal anti-ERCC1 antibody is suitable to detect ERCC1 in samples from Human. It has been validated for WB.

Quick Overview for ERCC1 antibody (ABIN7880754)

Target: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ERCC1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: AOFA-5

Product Details anti-ERCC1 Antibody

Purpose: ERCC1 Antibody

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human ERCC1 was used as the immunogen for the ERCC1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ERCC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the ERCC1 antibody at -20oC.

Target Details for ERCC1

Target: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Alternative Name: ERCC1

Background: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. [RefSeq]

UniProt: P07992

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response