Glutathione Peroxidase 1 antibody

Catalog No. ABIN7880892

The Rabbit Monoclonal anti-Glutathione Peroxidase 1 antibody is suitable to detect Glutathione Peroxidase 1 in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for Glutathione Peroxidase 1 antibody (ABIN7880892)

Target: Glutathione Peroxidase 1 (GPX1)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Glutathione Peroxidase 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IHO-7

Product Details anti-Glutathione Peroxidase 1 Antibody

Purpose: GPX1 Antibody / Glutathione Peroxidase 1

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Glutathione Peroxidase 1 / GPX1 was used as the immunogen for the GPX1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GPX1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the GPX1 antibody at -20oC.

Target Details for Glutathione Peroxidase 1

Target: Glutathione Peroxidase 1 (GPX1)

Alternative Name: GPX1

Background: The protein encoded by the GPX1 gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance, therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. [RefSeq]

UniProt: P07203

Pathways: Thyroid Hormone Synthesis, Sensory Perception of Sound, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome