GADD45B antibody

Catalog No. ABIN7880926

The Rabbit Polyclonal anti-GADD45B antibody (ABIN7880926) specifically detects GADD45B in WB and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for GADD45B antibody (ABIN7880926)

Target: GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GADD45B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GADD45B Antibody

Purpose: GADD45B Antibody

Sequence: EELLVAAQRQ DRLTVGVYE

Purification: Antigen affinity purified

Immunogen: Amino acids EELLVAAQRQDRLTVGVYE from the human protein were used as the immunogen for the GADD45B antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GADD45B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GADD45B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GADD45B

Target: GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))

Alternative Name: GADD45B

Background: Growth arrest and DNA-damage-inducible, beta, also known as GADD45B, is a protein which in humans is encoded by the GADD45B gene. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.

UniProt: O75293

Pathways: Cell Division Cycle