IMPDH2 antibody

Catalog No. ABIN7881162

The Rabbit Polyclonal anti-IMPDH2 antibody is suitable to detect IMPDH2 in samples from Human, Mouse and Rat. It has been validated for WB, IF, FACS and IHC (p).

Quick Overview for IMPDH2 antibody (ABIN7881162)

Target: IMPDH2 (IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 (IMPDH2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IMPDH2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IMPDH2 Antibody

Purpose: Inosine-5'-monophosphate dehydrogenase 2 Antibody / IMPDH2

Sequence: VVLSPKDRVR DVFEAKARH

Purification: Antigen affinity purified

Immunogen: Amino acids VVLSPKDRVRDVFEAKARH were used as the immunogen for the Inosine-5'-monophosphate dehydrogenase 2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Inosine-5'-monophosphate dehydrogenase 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Inosine-5'-monophosphate dehydrogenase 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for IMPDH2

Target: IMPDH2 (IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 (IMPDH2))

Alternative Name: Inosine-5'-monophosphate dehydrogenase 2

Background: Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene. This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

UniProt: P12268

Pathways: Ribonucleoside Biosynthetic Process, SARS-CoV-2 Protein Interactome