IDE antibody

Catalog No. ABIN7881183

The Rabbit Monoclonal anti-IDE antibody is suitable to detect IDE in samples from Human. It has been validated for WB.

Quick Overview for IDE antibody (ABIN7881183)

Target: IDE (Insulin-Degrading Enzyme (IDE))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This IDE antibody is un-conjugated

Application: Western Blotting (WB)

Clone: AOOB-9

Product Details anti-IDE Antibody

Purpose: IDE Antibody / Insulin degrading enzyme

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Insulin-degrading enzyme / IDE was used as the immunogen for the IDE antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the IDE antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the IDE antibody at -20oC.

Target Details for IDE

Target: IDE (Insulin-Degrading Enzyme (IDE))

Alternative Name: IDE

Background: The IDE gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [RefSeq]

UniProt: P14735

Pathways: SARS-CoV-2 Protein Interactome