Recombinant LAT antibody

Catalog No. ABIN7881473

The Rabbit Monoclonal anti-LAT antibody (Clone 28L72) (ABIN7881473) specifically detects LAT in WB. The antibody is reactive with Human samples.

Quick Overview for Recombinant LAT antibody (ABIN7881473)

Target: LAT (Linker For Activation of T Cells (LAT))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This LAT antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 28L72

Product Details anti-LAT Antibody

Purpose: LAT Antibody / Linker for Activation of T cells

Purification: Affinity chromatography

Immunogen: A synthetic peptide from human LAT protein was used as the immunogen for the LAT antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the LAT antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the LAT antibody at -20oC.

Target Details for LAT

Target: LAT (Linker For Activation of T Cells (LAT))

Alternative Name: LAT

Background: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. [UniProt]

UniProt: O43561

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway