MMP2 antibody

Catalog No. ABIN7881560

The Rabbit Monoclonal anti-MMP2 antibody (Clone BBA-13) (ABIN7881560) specifically detects MMP2 in WB and IHC (p). The antibody is reactive with Human and Rat samples.

Quick Overview for MMP2 antibody (ABIN7881560)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MMP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: BBA-13

Product Details anti-MMP2 Antibody

Purpose: MMP2 Antibody

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human MMP2 was used as the immunogen for the MMP2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MMP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the MMP2 antibody at -20oC.

Target Details for MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: MMP2

Background: The MMP2 gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. [RefSeq]

UniProt: P08253

Pathways: Activation of Innate immune Response