PLAT antibody

Catalog No. ABIN7881957

This Rabbit Polyclonal antibody specifically detects PLAT in WB, FACS and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PLAT antibody (ABIN7881957)

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAT antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PLAT Antibody

Purpose: tPA Antibody / Tissue Plasminogen Activator

Sequence: QKDVPGVYTK VTNYLDWIRD NMRP

Purification: Antigen affinity purified

Immunogen: Amino acids QKDVPGVYTKVTNYLDWIRDNMRP from the human protein were used as the immunogen for the tPA antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the tPA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the tPA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PLAT

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Alternative Name: tPA

Background: PLAT is also known as tPA. This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

UniProt: P00750

Pathways: Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome