Recombinant POLG antibody

Catalog No. ABIN7881999

This Rabbit Monoclonal antibody specifically detects POLG in WB. It exhibits reactivity toward Human.

Quick Overview for Recombinant POLG antibody (ABIN7881999)

Target: POLG (Polymerase (DNA Directed), gamma (POLG))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This POLG antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 24P93

Product Details anti-POLG Antibody

Purpose: POLG Antibody / DNA polymerase subunit gamma 1

Purification: Affinity chromatography

Immunogen: A peptide sequence specific to DNA polymerase subunit gamma 1 was used as the immunogen for the POLG antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the POLG antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the POLG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for POLG

Target: POLG (Polymerase (DNA Directed), gamma (POLG))

Alternative Name: POLG

Background: DNA polymerase subunit gamma 1 (POLG) is the catalytic subunit of the mitochondrial DNA polymerase complex, responsible for replication and repair of mitochondrial DNA. POLG ensures accurate DNA synthesis within mitochondria, which is essential for proper oxidative phosphorylation and cellular energy production.

Mutations in POLG are associated with a range of mitochondrial disorders, including progressive external ophthalmoplegia, Alpers-Huttenlocher syndrome, and ataxia-neuropathy syndromes. Studying POLG function helps researchers understand mitochondrial genome maintenance and the molecular basis of mitochondrial diseases.

Using a high-quality POLG antibody allows for sensitive detection of the protein in assays such as western blot, immunohistochemistry, and immunofluorescence. A POLG antibody from NSJ Bioreagents offers consistent performance, supporting studies in mitochondrial biology, genetic disorders, and DNA repair mechanisms. Choosing the right POLG antibody is critical for producing reliable and reproducible research results.

UniProt: P54098