Retinoblastoma Protein (Rb) antibody
Quick Overview for Retinoblastoma Protein (Rb) antibody (ABIN7882157)
Target
See all Retinoblastoma Protein (Rb) (Rb Protein) AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Purpose
- Retinoblastoma Antibody / Rb1
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Purification
- Affinity purified
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Immunogen
- A synthetic peptide specific to human Retinoblastoma / Rb was used as the immunogen for the Retinoblastoma antibody.
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Isotype
- IgG
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Application Notes
- Optimal dilution of the Retinoblastoma antibody should be determined by the researcher.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store the Retinoblastoma antibody at -20oC.
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- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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Alternative Name
- Retinoblastoma
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Background
- The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [RefSeq]
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UniProt
- P06400
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Pathways
- Mitotic G1-G1/S Phases
Target
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