SOCS1 antibody

Catalog No. ABIN7882391

The Rabbit Polyclonal anti-SOCS1 antibody (ABIN7882391) specifically detects SOCS1 in WB and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SOCS1 antibody (ABIN7882391)

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SOCS1 Antibody

Purpose: TIP3 Antibody / SOCS1 / SSI1

Sequence: FLVRDSRQRN CFFALSVKMA

Purification: Antigen affinity purified

Immunogen: Amino acids FLVRDSRQRNCFFALSVKMA were used as the immunogen for the TIP3 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TIP3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TIP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SOCS1

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Alternative Name: TIP3

Background: Suppressor of cytokine signaling 1 (SOCS1), also known as Jak-binding protein (JAB) and Tec-interacting protein 3 (TIP3), is a negative regulator to a subset of protein-tyrosine kinases. This 211-amino acid protein has a molecular mass of about 23.5 kD. The TEC-binding region of SOCS1 resides in the N terminus. SOCS1 associates with Tec and suppresses its kinase activity. The SOCS1 gene is intronless and is mapped to on chromosome 16p13.13. SOCS1 regulates the JAK/STAT signal-transduction pathway. Moreover, it contributes to protection against hepatic injury and fibrosis, and may also protect against hepatocarcinogenesis.

UniProt: O15524

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, TLR Signaling, Response to Growth Hormone Stimulus