TYMS antibody

Catalog No. ABIN7882469

The Rabbit Monoclonal anti-TYMS antibody (Clone ADAA-20) (ABIN7882469) specifically detects TYMS in WB. The antibody is reactive with Human, Mouse, Rat and Monkey samples.

Quick Overview for TYMS antibody (ABIN7882469)

Target: TYMS (Thymidylate Synthetase (TYMS))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TYMS antibody is un-conjugated

Application: Western Blotting (WB)

Clone: ADAA-20

Product Details anti-TYMS Antibody

Purpose: Thymidylate Synthase Antibody

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Thymidylate Synthase / TYMS was used as the immunogen for the Thymidylate Synthase antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Thymidylate Synthase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Thymidylate Synthase antibody at -20oC.

Target Details for TYMS

Target: TYMS (Thymidylate Synthetase (TYMS))

Alternative Name: Thymidylate Synthase

Background: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1, vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [RefSeq]

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases