Recombinant TIA1 antibody

Catalog No. ABIN7882488

This Rabbit Monoclonal antibody specifically detects TIA1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant TIA1 antibody (ABIN7882488)

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TIA1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TIA1-1352R

Product Details anti-TIA1 Antibody

Purpose: Recombinant TIA-1 Antibody / T-Cell Intracellular Antigen-1 (azide and preservative free)

Purification: Protein A affinity

Immunogen: Human bone marrow malignant cells from a non B, non T acute leukemia were used as the immunogen for the recombinant TIA-1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the recombinant TIA-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant TIA-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TIA1

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Alternative Name: TIA-1

Background: The T cell intracellular antigen 1 (TIA 1) is a 17 kDa cytoplasmic granule associated protein also designated as GMP 17, for granule membrane protein of 17 kDa. The GMP 17/TIA 1 Molecule is expressed in cells possessing cytolytic potential and could be involved in the signaling cascade of Fas (CD95) mediated apoptosis. Within hematopoietic cell lines, the TIA1/1352R monoclonal antibody reacts with about 90 % of CD16+, 50 60 % of CD8+, and less than 10 % of CD4+ normal peripheral blood lymphocytes. It reacts with almost all monocytes and granulocytes. This antibody also reacts with CD4+ activated T cell clones, activated NK cell clones, and Con activated thymocytes, but not with B lymphocytes or B cell lines. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.

UniProt: P31483