Neuregulin 3 antibody (Extracellular, N-Term)

Catalog No. ABIN7885165

The Rabbit Polyclonal anti-Neuregulin 3 antibody is suitable to detect Neuregulin 3 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for Neuregulin 3 antibody (Extracellular, N-Term) (ABIN7885165)

Target: Neuregulin 3 (NRG3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Grade: Carrier-free

Product Details anti-Neuregulin 3 Antibody

Binding Specificity: AA 167-180, Extracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to Neuregulin-3

Predicted Reactivity: Human,rat - identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)RFPGHRVPIRASPR, corresponding to amino acid residues 167-180 of mouse Neuregulin-3

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7236034)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for Neuregulin 3

Target: Neuregulin 3 (NRG3)

Alternative Name: Neuregulin-3

Background:

Synonyms: Neuregulin-3, HRG3

Description: Neuregulins (NRGs) are single-pass membrane proteins belonging to a multi member family of epidermal growth factor (EGF)-like signaling molecules involved in cell-cell communication. This family includes four human neuregulin paralogs NRG1-NRG4 with multiple isoforms through alternative splicing1.Neuregulin 3 (NRG3) plays a key role in the embryonic cerebral cortex development by regulating the migration and patterning of neural progenitor cells. It specifically binds to the ErbB4 receptor tyrosine kinase in the developing mammalian forebrain2,3.Neuregulin 3 is almost exclusively expressed in the nervous system with highest expression in the anterior cingulate and frontal cortex3,4.Mutations in the neuregulin 3 gene are linked to different mental disorders accompanied with cognitive and behavioral abnormalities such as developmental delay, cognitive impairment, and psychiatric illness2,3. Single nucleotide polymorphisms are associated with delusions in patients with schizophrenia and linked to the disease itself. Knockout mice display novelty-induced hyperactivity and are deficient fear conditioning4.

Gene ID: 18183

UniProt: O35181

Pathways: RTK Signaling