NRP2 antibody (Extracellular, N-Term)

Catalog No. ABIN7885192

The Rabbit Polyclonal anti-NRP2 antibody is suitable to detect NRP2 in samples from Human, Rat and Mouse. It has been validated for WB, IHC, IF and FACS.

Quick Overview for NRP2 antibody (Extracellular, N-Term) (ABIN7885192)

Target: NRP2 (Neuropilin 2 (NRP2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NRP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-NRP2 Antibody

Binding Specificity: AA 747-758, Extracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to Neuropilin-2

Predicted Reactivity: Rat,mouse - 11,12 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)REDQGGEWKHGR, corresponding to amino acid residues 747-758 of human neuropilin-2

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: 1:15

ICC: The optimal concentration should be determined by the user

IHC: 1:400

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7236118)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for NRP2

Target: NRP2 (Neuropilin 2 (NRP2))

Alternative Name: Vascular endothelial cell growth factor 165 receptor 2

Background:

Synonyms: Vascular endothelial cell growth factor 165 receptor 2, VEGF165R2

Description: The neuropilins (NRPs) are single-pass multifunctional transmembrane glycoproteins that play an important role in cell development, immunity and cancer, and physiological and pathological angiogenesis. They were first discovered as regulators of nervous system development, acting as semaphorin co-receptors with plexins, as well as enhancers of cellular responses to members of the vascular endothelial growth factor (VEGF) family.The NRP family comprises two members: Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2), which are usually expressed as homodimers but can also appear as heterodimers. NRP2 contains a large extracellular N-terminal which consists of five domains, a short transmembrane domain and a small cytoplasmic domain1-3. NRP2 is expressed in a wide variety of cells including endothelial cells, neurons, pancreatic islet cells, hepatocytes, melanocytes and osteoblasts. NRP2 has been shown to mediate proliferation, survival, and migration of tumor cells3.NRP2 knockout mice studies show that mice are viable without defects in blood vessels but display abnormal lymphatic development and defects of the central and peripheral nervous systems2.

Gene ID: 8828

UniProt: O60462

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals