5HT1D antibody (Extracellular, N-Term)

Catalog No. ABIN7885390

The Rabbit Polyclonal anti-5HT1D antibody is suitable to detect 5HT1D in samples from Mouse, Human and Rat. It has been validated for WB.

Quick Overview for 5HT1D antibody (Extracellular, N-Term) (ABIN7885390)

Target: 5HT1D (HTR1D) (Serotonin Receptor 1D (HTR1D))

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This 5HT1D antibody is un-conjugated

Application: Western Blotting (WB)

Grade: Carrier-free

Product Details anti-5HT1D Antibody

Binding Specificity: AA 14-27, Extracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1D

Predicted Reactivity: Mouse - identical, human - 13,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)EASNRSLNATGAWD, corresponding to amino acid residues 14-27 of rat 5-hydroxytryptamine receptor 1D

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7236788)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for 5HT1D

Target: 5HT1D (HTR1D) (Serotonin Receptor 1D (HTR1D))

Alternative Name: 5-Hydroxytryptamine receptor 1D

Background:

Synonyms: 5-Hydroxytryptamine receptor 1D, Serotonin receptor 1D, 5HT1D-alpha, HTR1DA

Description: Serotonin (5-hydroxytryptamine, 5-HT) plays unequivocally a most important role in the normal physiology amongst higher eukaryotes, as do most neurotransmitters. The physiological roles of serotonin and its receptors range from appetite, regulation of the circadian rhythm, sexual behavior, memory and nociception. Serotonin is also involved in migraine and some psychiatric diseases such as depression anxiety and aggression1. Serotonin and its receptors also have an influence on the cardiovascular, pulmonary, gastrointestinal (GI) and genitourinary systems2.To date, some fifteen serotonin receptors have been cloned and grouped into seven families (5-HT1-5-HT7) based on their signaling mechanisms. The 5-HT1 receptor class comprises 5 different receptors with ranging homology. Apart from 5-HT3, all serotonin receptors belong to the G-protein coupled receptor superfamily and therefore span the membrane seven times3.Members of the 5-HT1 receptor class all couple Gi/0 thereby inhibiting adenylate cyclase.In the central nervous system, 5-HT1D is expressed in the basal ganglia, hippocampus and cortex in the rat and in the basal ganglia, midbrain and spinal cord in the human. In serotonin neurons, 5-HT1D receptors are autoreceptors thereby inhibiting the release of 5-HT. In GABA, ACh, and glutamate neurons they are heteroreceptors where they control the release of these neurotransmitters4,5.The serotonin system plays an undeniable role in the perception and processing of pain. Indeed, many migraine sufferers are prescribed triptan-based drugs which activate 5-HT1B and 5-HT1D receptors2.

Gene ID: 25323

UniProt: P28565

Pathways: JAK-STAT Signaling