OGG1 antibody (N-Term) (Fluoro647)

Catalog No. ABIN7965273

The Fluoro647-conjugated Rabbit Polyclonal anti-OGG1 antibody (ABIN7965273) specifically detects OGG1 in FACS. The antibody is reactive with Human samples.

Quick Overview for OGG1 antibody (N-Term) (Fluoro647) (ABIN7965273)

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OGG1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-OGG1 Antibody (Fluoro647)

Binding Specificity: N-Term

Purpose: Anti-Ogg1 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Ogg1, which shares 89.7% and 87.2% amino acid (aa) sequence identity with mouse and rat Ogg1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for OGG1

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Alternative Name: OGG1

Background:

Background: 8-Oxoguanine glycosylase also known as OGG1 is a DNA glycosylase enzyme that, in humans, is encoded by theOGG1 gene. This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.

Gene Full Name: 8-oxoguanine DNA glycosylase

Gene ID: 4968

UniProt: O15527

Pathways: DNA Damage Repair