RAGE antibody (AA 24-320)

Catalog No. ABIN7967122

This Rabbit Polyclonal antibody specifically detects RAGE in WB and ELISA. It exhibits reactivity toward Mouse and Rat.

Quick Overview for RAGE antibody (AA 24-320) (ABIN7967122)

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAGE antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Product Details anti-RAGE Antibody

Binding Specificity: AA 24-320

Purpose: Anti-Ager Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Ager Antibody. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Ager recombinant protein (Position: Q24-E320).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Mouse, Rat ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for RAGE

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Alternative Name: Ager

Background:

Background: Enables S100 protein binding activity, advanced glycation end-product binding activity, and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta, negative regulation of long-term synaptic potentiation, and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis, negative regulation of advanced glycation end-product receptor activity, and positive regulation of macromolecule metabolic process. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system, brain, genitourinary system, hemolymphoid system gland, and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple), cardiovascular system disease (multiple), cystic fibrosis, kidney failure (multiple), and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor).

Gene Full Name: advanced glycosylation end product-specific receptor

Molecular Weight: 43 kDa, 58 kDa

Gene ID: 11596

UniProt: Q62151

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins