BAG2 antibody (AA 1-211) (APC)

Catalog No. ABIN7972328

The APC-conjugated Mouse Monoclonal anti-BAG2 antibody (Clone 8F11G2) (ABIN7972328) specifically detects BAG2 in FACS. The antibody is reactive with Human and Mouse samples.

Quick Overview for BAG2 antibody (AA 1-211) (APC) (ABIN7972328)

Target: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This BAG2 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: 8F11G2

Product Details anti-BAG2 Antibody (APC)

Binding Specificity: AA 1-211

Purpose: Anti-BAG2 Antibody (monoclonal, 8F11G2) APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human BAG2 shares 93.4% amino acid (aa) sequence identity with mouse BAG2.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human BAG2 recombinant protein (Position: M1-N211). Human BAG2 shares 93.4% amino acid (aa) sequence identity with mouse BAG2.

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for BAG2

Target: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Alternative Name: BAG2

Background:

Background: BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.

Gene Full Name: BAG cochaperone 2

Gene ID: 9532

UniProt: O95816