CAPNL1 antibody (AA 396-555) (Fluoro488)

Catalog No. ABIN7974294

This Rabbit Polyclonal antibody specifically detects CAPNL1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CAPNL1 antibody (AA 396-555) (Fluoro488) (ABIN7974294)

Target: CAPNL1 (Calpain 1, Large Subunit (CAPNL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAPNL1 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-CAPNL1 Antibody (Fluoro488)

Binding Specificity: AA 396-555

Purpose: Anti-Calpain 1/CAPN1 Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human Calpain 1 shares 86% amino acid (aa) sequence identity with both mouse,rat Calpain 1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Calpain 1 recombinant protein (Position: Q396-A555). Human Calpain 1 shares 86% amino acid (aa) sequence identity with both mouse and rat Calpain 1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CAPNL1

Target: CAPNL1 (Calpain 1, Large Subunit (CAPNL1))

Alternative Name: CAPN1

Background:

Background: CAPN1 is also known as CANP or muCL. The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.

Gene Full Name: calpain 1

Sequence Similarities: Belongs to the peptidase C2 family.

Gene ID: 823

UniProt: P07384

Pathways: Apoptosis