CIC antibody (AA 1433-1527) (Fluoro550)

Catalog No. ABIN7974559

The Rabbit Polyclonal anti-CIC antibody is suitable to detect CIC in samples from Mouse, Human and Rat. It has been validated for FACS.

Quick Overview for CIC antibody (AA 1433-1527) (Fluoro550) (ABIN7974559)

Target: CIC (Capicua Homolog (CIC))

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIC antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-CIC Antibody (Fluoro550)

Binding Specificity: AA 1433-1527

Purpose: Anti-CIC Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human CIC recombinant protein (Position: E1433-Q1527).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CIC

Target: CIC (Capicua Homolog (CIC))

Alternative Name: CIC

Background:

Background: Protein capicua homolog is a protein that in humans is encoded by the CIC gene. The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. This gene is mapped to 19q13.2. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Full Name: capicua transcriptional repressor

Gene ID: 23152

UniProt: Q96RK0