COMT antibody (AA 20-265) (HRP)

Catalog No. ABIN7975652

The HRP-conjugated Rabbit Polyclonal anti-COMT antibody (ABIN7975652) specifically detects COMT in WB, IHC and ELISA. The antibody is reactive with Rat and Mouse samples.

Quick Overview for COMT antibody (AA 20-265) (HRP) (ABIN7975652)

Target: COMT (Catechol-O-Methyltransferase (COMT))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COMT antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-COMT Antibody (HRP)

Binding Specificity: AA 20-265

Purpose: Anti-COMT Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived mouse COMT recombinant protein (Position: R20-S265).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for COMT

Target: COMT (Catechol-O-Methyltransferase (COMT))

Alternative Name: Comt

Background:

Background: Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini.

Gene Full Name: catechol-O-methyltransferase

Gene ID: 12846

UniProt: O88587

Pathways: Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interactome