CCR1 antibody (C-Term) (Fluoro647)

Catalog No. ABIN7978814

The Fluoro647-conjugated Rabbit Polyclonal anti-CCR1 antibody (ABIN7978814) specifically detects CCR1 in FACS. The antibody is reactive with Mouse and Rat samples.

Quick Overview for CCR1 antibody (C-Term) (Fluoro647) (ABIN7978814)

Target: CCR1 (Chemokine (C-C Motif) Receptor 1 (CCR1))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-CCR1 Antibody (Fluoro647)

Binding Specificity: C-Term

Purpose: Anti-CCR1 Antibody Fluoro647 Conjugated

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse CCR1, which shares 73.7% amino acid (aa) sequence identity with human CCR1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CCR1

Target: CCR1 (Chemokine (C-C Motif) Receptor 1 (CCR1))

Alternative Name: CCR1

Background:

Background: C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.

Gene Full Name: C-C motif chemokine receptor 1

Gene ID: 12768

UniProt: P51675