CDSE1 antibody (AA 1-775) (HRP)

Catalog No. ABIN7980992

The HRP-conjugated Rabbit Polyclonal anti-CDSE1 antibody (ABIN7980992) specifically detects CDSE1 in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for CDSE1 antibody (AA 1-775) (HRP) (ABIN7980992)

Target: CDSE1 (Cold Shock Domain Containing E1, RNA-Binding (CDSE1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDSE1 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-CDSE1 Antibody (HRP)

Binding Specificity: AA 1-775

Purpose: Anti-CSDE1/NRU Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CSDE1/NRU recombinant protein (Position: M1-Q775).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CDSE1

Target: CDSE1 (Cold Shock Domain Containing E1, RNA-Binding (CDSE1))

Alternative Name: CSDE1

Background:

Background: Cold shock domain-containing protein E1 is a protein that in humans is encoded by the CSDE1 gene. Originally described as the product of an active transcription unit located upstream of the N-RAS gene, CSDE1 (cold shock domain-containing protein E1) is a highly conserved RNA-binding protein containing five cold-shock domains. CSDE1 is mostly localized in the cytoplasm where it interacts with distinct protein complexes involved in the post-transcriptional regulation of numerous mRNAs in a dynamic and complex manner. CSDE1 plays a role in maintaining the undifferentiated state of human embryonic stem cells (hESCs), and its loss results in accelerated neural differentiation and neurogenesis, partially via post-transcriptional regulation of fatty acid binding protein 7 (FABP7) and vimentin (VIM) mRNAs. In human melanoma, increased CSDE1 protein expression has been shown to modulate the levels of pro-oncogenic factors such as vimentin or RAC1 and tumor suppressors such as PTEN, thus promoting tumor invasion and metastasis.

Gene Full Name: cold shock domain containing E1

Gene ID: 7812

UniProt: O75534

Pathways: SARS-CoV-2 Protein Interactome