CDSE1 antibody (AA 1-775) (PE)

Catalog No. ABIN7980994

The Rabbit Polyclonal anti-CDSE1 antibody is suitable to detect CDSE1 in samples from Human. It has been validated for FACS.

Quick Overview for CDSE1 antibody (AA 1-775) (PE) (ABIN7980994)

Target: CDSE1 (Cold Shock Domain Containing E1, RNA-Binding (CDSE1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDSE1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-CDSE1 Antibody (PE)

Binding Specificity: AA 1-775

Purpose: Anti-CSDE1/NRU Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CSDE1/NRU recombinant protein (Position: M1-Q775).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CDSE1

Target: CDSE1 (Cold Shock Domain Containing E1, RNA-Binding (CDSE1))

Alternative Name: CSDE1

Background:

Background: Cold shock domain-containing protein E1 is a protein that in humans is encoded by the CSDE1 gene. Originally described as the product of an active transcription unit located upstream of the N-RAS gene, CSDE1 (cold shock domain-containing protein E1) is a highly conserved RNA-binding protein containing five cold-shock domains. CSDE1 is mostly localized in the cytoplasm where it interacts with distinct protein complexes involved in the post-transcriptional regulation of numerous mRNAs in a dynamic and complex manner. CSDE1 plays a role in maintaining the undifferentiated state of human embryonic stem cells (hESCs), and its loss results in accelerated neural differentiation and neurogenesis, partially via post-transcriptional regulation of fatty acid binding protein 7 (FABP7) and vimentin (VIM) mRNAs. In human melanoma, increased CSDE1 protein expression has been shown to modulate the levels of pro-oncogenic factors such as vimentin or RAC1 and tumor suppressors such as PTEN, thus promoting tumor invasion and metastasis.

Gene Full Name: cold shock domain containing E1

Gene ID: 7812

UniProt: O75534

Pathways: SARS-CoV-2 Protein Interactome