Cortactin antibody (AA 1-105) (Fluoro550)

Catalog No. ABIN7981715

The Fluoro550-conjugated Rabbit Polyclonal anti-Cortactin antibody (ABIN7981715) specifically detects Cortactin in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Cortactin antibody (AA 1-105) (Fluoro550) (ABIN7981715)

Target: Cortactin (CTTN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cortactin antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-Cortactin Antibody (Fluoro550)

Binding Specificity: AA 1-105

Purpose: Anti-Cortactin/CTTN Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Cortactin recombinant protein (Position: M1-Q105).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Cortactin

Target: Cortactin (CTTN)

Alternative Name: CTTN

Background:

Background: Cortactin, mapped to 11q13.3, is a multidomain protein. This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

Gene Full Name: cortactin

UniProt: Q14247

Pathways: MAPK Signaling