Desmocollin 3 antibody (AA 87-676) (Fluoro647)

Catalog No. ABIN7984975

The Rabbit Polyclonal anti-Desmocollin 3 antibody is suitable to detect Desmocollin 3 in samples from Human and Rat. It has been validated for FACS.

Quick Overview for Desmocollin 3 antibody (AA 87-676) (Fluoro647) (ABIN7984975)

Target: Desmocollin 3 (DSC3)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmocollin 3 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-Desmocollin 3 Antibody (Fluoro647)

Binding Specificity: AA 87-676

Purpose: Anti-DSC3 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human DSC3 recombinant protein (Position: L87-Q676).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Desmocollin 3

Target: Desmocollin 3 (DSC3)

Alternative Name: DSC3

Background:

Background: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.

Gene Full Name: desmocollin 3

Gene ID: 1825

UniProt: Q14574