DAB2 antibody (AA 89-770) (PE)

Catalog No. ABIN7985547

This Rabbit Polyclonal antibody specifically detects DAB2 in FACS. It exhibits reactivity toward Human, Mouse, Rat and Monkey.

Quick Overview for DAB2 antibody (AA 89-770) (PE) (ABIN7985547)

Target: DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAB2 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-DAB2 Antibody (PE)

Binding Specificity: AA 89-770

Purpose: Anti-DAB2 Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human DAB2 recombinant protein (Position: H89-A770).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for DAB2

Target: DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))

Alternative Name: DAB2

Background:

Background: Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene. This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: DAB adaptor protein 2

Gene ID: 1601

UniProt: P98082

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process