DRD5 antibody (AA 1-477) (Fluoro550)

Catalog No. ABIN7986265

The Rabbit Polyclonal anti-DRD5 antibody is suitable to detect DRD5 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for DRD5 antibody (AA 1-477) (Fluoro550) (ABIN7986265)

Target: DRD5 (Dopamine Receptor D5 (DRD5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DRD5 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-DRD5 Antibody (Fluoro550)

Binding Specificity: AA 1-477

Purpose: Anti-DRD5 Antibody Fluoro550 Conjugated

Predicted Reactivity: Human DRD5 shares 82.3%,82.4% amino acid (aa) sequence identity with mouse,rat DRD5,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human DRD5 recombinant protein (Position: M1-H477). Human DRD5 shares 82.3% and 82.4% amino acid (aa) sequence identity with mouse and rat DRD5, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for DRD5

Target: DRD5 (Dopamine Receptor D5 (DRD5))

Alternative Name: DRD5

Background:

Background: D(1B) dopamine receptor(DRD5), also called DRD1B or DRD1L2 is a protein that in humans is encoded by the DRD5 gene. This gene is mapped to 4p16.1. This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. Compared with DRD1, DRD5 displayed a higher affinity for dopamine and was able to stimulate a biphasic rather than a monophasic intracellular accumulation of cAMP.

Gene Full Name: dopamine receptor D5

Gene ID: 1816

UniProt: P21918

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity