Dynamin 1-Like antibody (AA 452-736)

Catalog No. ABIN7986577

The Rabbit Polyclonal anti-Dynamin 1-Like antibody is suitable to detect Dynamin 1-Like in samples from Human and Rat. It has been validated for WB and ELISA.

Quick Overview for Dynamin 1-Like antibody (AA 452-736) (ABIN7986577)

Target: Dynamin 1-Like (DNM1L)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynamin 1-Like antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Product Details anti-Dynamin 1-Like Antibody

Binding Specificity: AA 452-736

Purpose: Anti-DRP1/DNM1L Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-DRP1/DNM1L Antibody. Tested in ELISA, WB applications. This antibody reacts with Human, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human DRP1/DNM1L recombinant protein (Position: Q452-W736).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Rat ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Dynamin 1-Like

Target: Dynamin 1-Like (DNM1L)

Alternative Name: DNM1L

Background:

Background: Dynamin-1-like protein is a GTPase that regulates mitochondrial fission. In humans, dynamin-1-like protein, which is typically referred to as dynamin-related protein 1 (Drp1), is encoded by the DNM1L gene. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Full Name: dynamin 1 like

Molecular Weight: 75 kDa

Gene ID: 10059

UniProt: O00429