EXOSC2 antibody (AA 62-293) (APC)

Catalog No. ABIN7989338

The APC-conjugated Rabbit Polyclonal anti-EXOSC2 antibody (ABIN7989338) specifically detects EXOSC2 in FACS. The antibody is reactive with Human samples.

Quick Overview for EXOSC2 antibody (AA 62-293) (APC) (ABIN7989338)

Target: EXOSC2 (Exosome Component 2 (EXOSC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC2 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-EXOSC2 Antibody (APC)

Binding Specificity: AA 62-293

Purpose: Anti-RRP4/EXOSC2 Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human RRP4/EXOSC2 recombinant protein (Position: R62-G293).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for EXOSC2

Target: EXOSC2 (Exosome Component 2 (EXOSC2))

Alternative Name: EXOSC2

Background:

Background: Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snoRNA and snRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. EXOSC2 is a non-catalytic component of the RNA exosome complex that has 3'->5' exoribonuclease activity and involves in a multitude of cellular RNA processing and degradation events.

Gene Full Name: exosome component 2

Gene ID: 23404

UniProt: Q13868

Pathways: SARS-CoV-2 Protein Interactome