EXOSC2 antibody (AA 62-293)

Catalog No. ABIN7989341

The Rabbit Polyclonal anti-EXOSC2 antibody (ABIN7989341) specifically detects EXOSC2 in WB, IHC, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for EXOSC2 antibody (AA 62-293) (ABIN7989341)

Target: EXOSC2 (Exosome Component 2 (EXOSC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-EXOSC2 Antibody

Binding Specificity: AA 62-293

Purpose: Anti-RRP4/EXOSC2 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-RRP4/EXOSC2 Antibody. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human RRP4/EXOSC2 recombinant protein (Position: R62-G293).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for EXOSC2

Target: EXOSC2 (Exosome Component 2 (EXOSC2))

Alternative Name: EXOSC2

Background:

Background: Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snoRNA and snRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. EXOSC2 is a non-catalytic component of the RNA exosome complex that has 3'->5' exoribonuclease activity and involves in a multitude of cellular RNA processing and degradation events.

Gene Full Name: exosome component 2

Molecular Weight: 33 kDa

Gene ID: 23404

UniProt: Q13868

Pathways: SARS-CoV-2 Protein Interactome