FDPS antibody (AA 29-397) (HRP)

Catalog No. ABIN7989657

This Rabbit Polyclonal antibody specifically detects FDPS in WB, IHC and ELISA. It exhibits reactivity toward Human and Rat.

Quick Overview for FDPS antibody (AA 29-397) (HRP) (ABIN7989657)

Target: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FDPS antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-FDPS Antibody (HRP)

Binding Specificity: AA 29-397

Purpose: Anti-FDPS/FPS Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FDPS/FPS recombinant protein (Position: S29-Q397).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for FDPS

Target: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Alternative Name: FDPS

Background:

Background: Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene. It is mapped to 1q22. This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: farnesyl diphosphate synthase

Gene ID: 2224

UniProt: P14324

Pathways: Regulation of Muscle Cell Differentiation