Fibronectin 1 antibody (AA 869-2014) (Fluoro488)

Catalog No. ABIN7990810

The Rabbit Polyclonal anti-Fibronectin 1 antibody is suitable to detect Fibronectin 1 in samples from Human. It has been validated for FACS.

Quick Overview for Fibronectin 1 antibody (AA 869-2014) (Fluoro488) (ABIN7990810)

Target: Fibronectin 1 (FN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Fibronectin 1 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-Fibronectin 1 Antibody (Fluoro488)

Binding Specificity: AA 869-2014

Purpose: Anti-Fibronectin/FN1 Antibody Fluoro488 Conjugated

Predicted Reactivity: Human FN1 shares 91.2%,91.4% amino acid (aa) sequence identity with mouse,rat FN1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Fibronectin/FN1 recombinant protein (Position: D869-W2014). Human FN1 shares 91.2% and 91.4% amino acid (aa) sequence identity with mouse and rat FN1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Fibronectin 1

Target: Fibronectin 1 (FN1)

Alternative Name: FN1

Background:

Background: Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. It is mapped to 2q35. This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.

Gene Full Name: fibronectin 1

Gene ID: 2335

UniProt: P02751

Pathways: Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy