FHIT antibody (AA 1-147) (FITC)

Catalog No. ABIN7991727

This Rabbit Polyclonal antibody specifically detects FHIT in FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for FHIT antibody (AA 1-147) (FITC) (ABIN7991727)

Target: FHIT (Fragile Histidine Triad (FHIT))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FHIT antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-FHIT Antibody (FITC)

Binding Specificity: AA 1-147

Purpose: Anti-FHIT Antibody FITC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human FHIT shares 90%,87% amino acid (aa) sequences identity with mouse,rat FHIT,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FHIT recombinant protein (Position: M1-Q147). Human FHIT shares 90% and 87% amino acid (aa) sequences identity with mouse and rat FHIT, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for FHIT

Target: FHIT (Fragile Histidine Triad (FHIT))

Alternative Name: FHIT

Background:

Background: Bis (5'-adenosyl)-triphosphatase, also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis (5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3p14.2, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Furthermore, FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. It also acts as a tumor suppressor of HER2/neu driven breast cancer.

Gene Full Name: fragile histidine triad diadenosine triphosphatase

Sequence Similarities: Contains 1 HIT domain.

Gene ID: 2272

UniProt: P49789