GNS antibody (AA 238-355) (Cy3)

Catalog No. ABIN7993423

The Rabbit Polyclonal anti-GNS antibody is suitable to detect GNS in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for GNS antibody (AA 238-355) (Cy3) (ABIN7993423)

Target: GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNS antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-GNS Antibody (Cy3)

Binding Specificity: AA 238-355

Purpose: Anti-GNS Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human GNS recombinant protein (Position: W238-R355).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for GNS

Target: GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))

Alternative Name: GNS

Background:

Background: N-acetylglucosamine-6-sulfatase, also known as glucosamine (N-acetyl)-6-sulfatase, is an enzyme that in humans is encoded by the GNS gene. The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.

Gene Full Name: glucosamine (N-acetyl)-6-sulfatase

Gene ID: 2799

UniProt: P15586

Pathways: Glycosaminoglycan Metabolic Process