GNS antibody (AA 238-355) (HRP)

Catalog No. ABIN7993428

This Rabbit Polyclonal antibody specifically detects GNS in WB, ELISA and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GNS antibody (AA 238-355) (HRP) (ABIN7993428)

Target: GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNS antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-GNS Antibody (HRP)

Binding Specificity: AA 238-355

Purpose: Anti-GNS Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human GNS recombinant protein (Position: W238-R355).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GNS

Target: GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))

Alternative Name: GNS

Background:

Background: N-acetylglucosamine-6-sulfatase, also known as glucosamine (N-acetyl)-6-sulfatase, is an enzyme that in humans is encoded by the GNS gene. The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.

Gene Full Name: glucosamine (N-acetyl)-6-sulfatase

Gene ID: 2799

UniProt: P15586

Pathways: Glycosaminoglycan Metabolic Process