GLUD1 / GLUD2 (AA 54-553) antibody (HRP)

Catalog No. ABIN7993582

The Rabbit Polyclonal anti-GLUD1 / GLUD2 antibody is suitable to detect GLUD1 / GLUD2 in samples from Human, Mouse and Rat. It has been validated for ELISA, WB and IHC.

Quick Overview for GLUD1 / GLUD2 (AA 54-553) antibody (HRP) (ABIN7993582)

Target: GLUD1 / GLUD2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: HRP

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details

Binding Specificity: AA 54-553

Purpose: Anti-GLUD1/2 Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human GLUD1/2 recombinant protein (Position: S54-A553).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details

Target: GLUD1 / GLUD2

Alternative Name: GLUD1/2

Background:

Background: This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.

Gene Full Name: glutamate dehydrogenase 1/2

Gene ID: 2746, 2747

UniProt: P00367