GADD45B antibody (N-Term) (FITC)

Catalog No. ABIN7995190

The Rabbit Polyclonal anti-GADD45B antibody is suitable to detect GADD45B in samples from Human. It has been validated for FACS.

Quick Overview for GADD45B antibody (N-Term) (FITC) (ABIN7995190)

Target: GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GADD45B antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-GADD45B Antibody (FITC)

Binding Specificity: N-Term

Purpose: Anti-GADD45B Antibody FITC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human GADD45B, which shares 94.7% amino acid (aa) sequence identity with mouse GADD45B.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for GADD45B

Target: GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))

Alternative Name: GADD45B

Background:

Background: Growth arrest and DNA-damage-inducible, beta, also known as GADD45B, is a protein which in humans is encoded by the GADD45B gene. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.

Gene Full Name: growth arrest and DNA damage inducible beta

Gene ID: 4616

UniProt: O75293

Pathways: Cell Division Cycle