GADD45B antibody (N-Term)

Catalog No. ABIN7995195

This Rabbit Polyclonal antibody specifically detects GADD45B in IHC and WB. It exhibits reactivity toward Human.

Quick Overview for GADD45B antibody (N-Term) (ABIN7995195)

Target: GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GADD45B antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Grade: Carrier-free

Product Details anti-GADD45B Antibody

Binding Specificity: N-Term

Purpose: Anti-GADD45B Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-GADD45B Antibody. Tested in IHC, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human GADD45B, which shares 94.7% amino acid (aa) sequence identity with mouse GADD45B.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GADD45B

Target: GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))

Alternative Name: GADD45B

Background:

Background: Growth arrest and DNA-damage-inducible, beta, also known as GADD45B, is a protein which in humans is encoded by the GADD45B gene. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.

Gene Full Name: growth arrest and DNA damage inducible beta

Molecular Weight: 18 kDa

Gene ID: 4616

UniProt: O75293

Pathways: Cell Division Cycle