HSD17B10 antibody (AA 48-261) (Fluoro550)

Catalog No. ABIN7998766

The Rabbit Polyclonal anti-HSD17B10 antibody is suitable to detect HSD17B10 in samples from Human. It has been validated for FACS.

Quick Overview for HSD17B10 antibody (AA 48-261) (Fluoro550) (ABIN7998766)

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B10 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-HSD17B10 Antibody (Fluoro550)

Binding Specificity: AA 48-261

Purpose: Anti-ERAB/HSD17B10 Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human ERAB shares 87%,88% amino acid (aa) sequence identity with mouse,rat ERAB,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human ERAB recombinant protein (Position: E48-P261). Human ERAB shares 87% and 88% amino acid (aa) sequence identity with mouse and rat ERAB, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for HSD17B10

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Alternative Name: HSD17B10

Background:

Background: ERAB is also known as HSD17B10 or HADH2. This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Gene Full Name: hydroxysteroid 17-beta dehydrogenase 10

Gene ID: 3028

UniProt: Q99714