ITGA4 antibody (AA 41-963) (Fluoro594)

Catalog No. ABIN8000334

The Rabbit Polyclonal anti-ITGA4 antibody is suitable to detect ITGA4 in samples from Mouse and Rat. It has been validated for FACS.

Quick Overview for ITGA4 antibody (AA 41-963) (Fluoro594) (ABIN8000334)

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA4 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-ITGA4 Antibody (Fluoro594)

Binding Specificity: AA 41-963

Purpose: Anti-Integrin Alpha 4/Itga4 Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Mouse Itga4 shares 85.2% amino acid (aa) sequence identity with human Itga4.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Integrin Alpha 4/Itga4 recombinant protein (Position: Y41-D963). Mouse Itga4 shares 85.2% amino acid (aa) sequence identity with human Itga4.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Alternative Name: Itga4

Background:

Background: CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants.

Gene Full Name: integrin alpha 4

Gene ID: 16401

UniProt: Q00651

Pathways: Integrin Complex