IL2RG antibody (N-Term) (Fluoro647)

Catalog No. ABIN8002297

The Fluoro647-conjugated Rabbit Polyclonal anti-IL2RG antibody (ABIN8002297) specifically detects IL2RG in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for IL2RG antibody (N-Term) (Fluoro647) (ABIN8002297)

Target: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL2RG antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-IL2RG Antibody (Fluoro647)

Binding Specificity: N-Term

Purpose: Anti-IL2 Receptor gamma/IL2RG Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human IL2 Receptor gamma/IL2RG, which shares 78.9% amino acid (aa) sequence identity with both mouse and rat IL2 Receptor gamma/IL2RG.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for IL2RG

Target: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Alternative Name: IL2RG

Background:

Background: IL2RG (INTERLEUKIN 2 RECEPTOR, GAMMA),also known as Common gamma chain or CD132, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors:IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. IL2RG is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. By fluorescence in situ hybridization and PCR amplification of somatic cell hybrid DNAs, The IL2RG gene is mapped to Xq13.1. The IL2RG gene contains 8 exons and spans approximately 4.2 kb. And the gamma chain is an indispensable component of the functional IL2 receptor. Lymphocytes expressing the common gamma chain can form functional receptors for these cytokine proteins, which transmit signals from one cell to another and programs of cellular differentiation. The sharing of the gamma subunit by several receptors explains why humans and mice that lack IL2 entirely show milder symptoms than those with IL2RG deficiency.

Gene Full Name: interleukin 2 receptor subunit gamma

Gene ID: 3561

UniProt: P31785

Pathways: JAK-STAT Signaling, Growth Factor Binding