IL2RG antibody (Middle Region) (APC)

Catalog No. ABIN8002306

The APC-conjugated Rabbit Polyclonal anti-IL2RG antibody (ABIN8002306) specifically detects IL2RG in FACS. The antibody is reactive with Human samples.

Quick Overview for IL2RG antibody (Middle Region) (APC) (ABIN8002306)

Target: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL2RG antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-IL2RG Antibody (APC)

Binding Specificity: Middle Region

Purpose: Anti-IL2 Receptor gamma/IL2RG Antibody APC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human IL2 Receptor gamma.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for IL2RG

Target: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Alternative Name: IL2RG

Background:

Background: IL2RG (INTERLEUKIN 2 RECEPTOR, GAMMA),also known as Common gamma chain or CD132, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors:IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. IL2RG is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. By fluorescence in situ hybridization and PCR amplification of somatic cell hybrid DNAs, The IL2RG gene is mapped to Xq13.1. The IL2RG gene contains 8 exons and spans approximately 4.2 kb. And the gamma chain is an indispensable component of the functional IL2 receptor. Lymphocytes expressing the common gamma chain can form functional receptors for these cytokine proteins, which transmit signals from one cell to another and programs of cellular differentiation. The sharing of the gamma subunit by several receptors explains why humans and mice that lack IL2 entirely show milder symptoms than those with IL2RG deficiency.

Gene Full Name: interleukin 2 receptor subunit gamma

Sequence Similarities: Belongs to the type I cytokine receptor family. Type 5 subfamily.

Gene ID: 3561

UniProt: P31785

Pathways: JAK-STAT Signaling, Growth Factor Binding