MMP2 antibody (AA 429-660) (Fluoro647)

Catalog No. ABIN8008306

The Fluoro647-conjugated Rabbit Polyclonal anti-MMP2 antibody (ABIN8008306) specifically detects MMP2 in FACS. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for MMP2 antibody (AA 429-660) (Fluoro647) (ABIN8008306)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP2 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-MMP2 Antibody (Fluoro647)

Binding Specificity: AA 429-660

Purpose: Anti-MMP2 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: coli-derived human MMP2 recombinant protein (Position: K429-C660). Human MMP2 shares 95.7%,95.3% amino acid (aa) sequence identity with mouse,rat MMP2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human MMP2 recombinant protein (Position: K429-C660). Human MMP2 shares 95.7% and 95.3% amino acid (aa) sequence identity with mouse and rat MMP2, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: MMP2

Background:

Background: Matrix metalloproteinase-2 (MMP2) is a Type IV collagenase, 72-kD, which is also known as gelatinase and is a member of a group of secreted zinc metalloproteases. The MMP2 gene is 17 kb long with 13 exons varying in size from 110 to 901 bp and 12 introns ranging from 175 to 4,350 bp, located within a region of human chromosome 16q13. In addition, the extra exons encode the amino acids of the fibronectin-like domain which has so far been found in only the 72- and 92- kDa type IV collagenase. MMP2, which has a critical role in the binding of progelatinase A and TIMP4 via the C-terminal hemopexin-like domain (C domain), is functionally associated on the surface of angiogenic blood vessels. Not only is a likely effector of endometrial menstrual breakdown, MMP2 is also effector and regulator of the inflammatory response. Moreover, MMP2 could be helpful in diagnosing Takayasu arteritis.

Gene Full Name: matrix metallopeptidase 2

Gene ID: 4313

UniProt: P08253

Pathways: Activation of Innate immune Response