MDM4-binding Protein antibody (AA 8-490) (Fluoro488)

Catalog No. ABIN8008497

The Rabbit Polyclonal anti-MDM4-binding Protein antibody is suitable to detect MDM4-binding Protein in samples from Human. It has been validated for FACS.

Quick Overview for MDM4-binding Protein antibody (AA 8-490) (Fluoro488) (ABIN8008497)

Target: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MDM4-binding Protein antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-MDM4-binding Protein Antibody (Fluoro488)

Binding Specificity: AA 8-490

Purpose: Anti-MDMX/MDM4 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MDMX/MDM4 recombinant protein (Position: A8-A490).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MDM4-binding Protein

Target: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Alternative Name: MDM4

Background:

Background: Protein Mdm4?is a?protein?that in humans is encoded by the?MDM4?gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene Full Name: MDM4 regulator of p53

Gene ID: 4194

UniProt: O15151

Pathways: Cell Division Cycle