MEFV antibody (AA 463-781) (Fluoro488)

Catalog No. ABIN8008739

This Rabbit Polyclonal antibody specifically detects MEFV in FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for MEFV antibody (AA 463-781) (Fluoro488) (ABIN8008739)

Target: MEFV (Mediterranean Fever (MEFV))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEFV antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-MEFV Antibody (Fluoro488)

Binding Specificity: AA 463-781

Purpose: Anti-Pyrin/MEFV Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Pyrin/MEFV recombinant protein (Position: Q463-D781).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MEFV

Target: MEFV (Mediterranean Fever (MEFV))

Alternative Name: MEFV

Background:

Background: MEFV (Mediterranean fever) is a human gene that provides instructions for making a protein called pyrin (also known as marenostrin). Pyrin is produced in certain white blood cells (neutrophils, eosinophils and monocytes) that play a role in inflammation and in fighting infection. Inside these white blood cells, pyrin is found with thecytoskeleton, the structural framework that helps to define the shape, size, and movement of a cell. Pyrin's protein structure also allows it to interact with other molecules involved in fighting infection and in the inflammatory response. Although pyrin's function is not fully understood, it likely assists in keeping the inflammation process under control. Research indicates that pyrin helps regulate inflammation by interacting with the cytoskeleton. And Pyrin may the migration of white blood cells to sites of inflammation and stop or slow the inflammatory response when it is no longer needed.

Gene Full Name: MEFV innate immunity regulator, pyrin

Gene ID: 4210

UniProt: O15553

Pathways: Positive Regulation of Endopeptidase Activity